infection
Neurobrucellosis
16 September 2023
Brucellosis is a zoonotic infection transmitted to humans from animals (cattle, goats, sheep) via The UK is a non-endemic country. Most brucella cases in the UK are imported cases with links to Mediterranean or Middle Eastern countries. However, Brucella is also endemic in Central Asia, China, South Asia, sub-Saharan Africa, and some parts of Middle and […]
Infection associated with chronic granulomatous disease (CGD)
16 September 2023
Introduction CGD is a rare inherited immunodeficiency disorder where the NADPH oxidase in the phagocytic cells is absent or malfunctioning. Most CGDs are inherited as X linked, while the rest are autosomal recessive. Phagocytes, like neutrophils and monocytes, in the absence of NADPH oxidase, cannot kill the ingested pathogens due to the lack of oxidative burst. As a result, […]