Ibrexafungerp, an enfumafungin derivative, belongs to a new family called triterpenoid antifungals.This is a new class called “-fungerp”. This antifungal class inhibits glucan synthetase required for fungal cell wall synthesis. One of the major antifungal class echinocandins also acts by this mechanism and has been used since 2001. Echinocandins, however, have poor bioavailability and are…
Emergomycosis is a systemic fungal mycosis caused by a novel dimorphic fungi called Emergomyces species. It is mainly seen in immunocompromised patients. The first case of Emergomycosis was identified in 1994 in Italy; however, the fungus was described in 1998. Disseminated Emergomycosis observed a case fatality rate of 48%. These fungi were initially classified as…
Introduction Candida auris is a pathogen that has emerged as a global threat in recent years. It is the first human pathogenic fungus subject to international health alerts. The reason behind these concerns are – Public Health England reported in 2017 that almost all the C auris in the UK are fluconazole-resistant. There is also…
The Fungus: Identification: It initially forms white colonies with a yellow back, which quickly becomes black. Conidia is rough, brownish-black, biseriate, and covers the entire vesicle. A key feature in diagnosing A. niger infection is the presence of calcium oxalate crystals on pathological examination. The presence of crystals can be taken as an indication of A niger…
For FRCPath Microbiology, I consider the fungi highlighted in yellow are must-read. Grey highlighted ones – if you have time.
