Antifungals
Antifungals – Synergy, indifference and antagonism
A combination of antifungals is often used in cases of difficult-to-treat infections. What is the evidence in the literature about synergy, antagonism and indifference? Drug 1 Drug 2 Candida Aspergillus Cryptococcus neoformans Amphotericin B Echinocandin Indifference(survival – NA) Synergy, Indifference(Survival ↑) Synergy(survival – NA) Amphotericin B Flucytosine Synergy, indifference(Survival ↑) Synergy, indifference, antagonism(Survival ↑) Synergy, […]
Echinocandin
Echinocandins are a class of antifungals that prevent glucan synthesis pathways necessary for fungal cell wall formation. Echinocanins are antifungals that are widely used in clinical practice.Three echinocandins are approved for clinical use – Caspofungin, Micafungin and Anidulafungin.A fourth echinocandin – Rezafungin is being developed. Some other antifungals (some in development) that act of fungal cell walls […]