fosfomycin

Fosfomycin

Nature: Small (Mol weight – 138) phosphoenolpyruvate analogue manufactured synthetically but originally obtained from Streptomyces fradiae and some Pseudomonas sp.A broad-spectrum, a bactericidal antibiotic. Mechanism of action: Inhibit bacterial cell wall formation at a very early stage by inactivating enol pyruvate transferase (MurA).MurA catalyzes the transfer of enolpyruvate from phosphoenolphyruvate to uridine diphospho-N-acetylglucosamine (UNAG), the first step […]