Daptomycin

Class: Cyclic lipopeptideSource: Streptomyces roseosporusDiscovered: 1980s; approved for use in 2003 (FDA)Molecular weight: 1620 DA. Mechanism of action: The Daptomycin (DAP) combines with Calcium ions to form a positively charged complex that attaches to the bacterial cell membrane (preferably at the nascent septa). This attachment depends upon the presence of phospholipid phosphatidylglycerol (PG). After attachment, DAP forms…