Leclercia adecarboxylata

While authorising the urine result – I found that a urine sample from the community has grown Leclercia adecarboxylata. The patient is a young female complaining of increased frequency. The number of organisms in the urine was >100,000 organisms/ml.What is the significance? The bacteria  Previously known as Escherichia adecarboxylata, it now belongs to a new genus Leclercia…

Read More

Dengue vaccine – Greenbook Summary

Vaccine Description and Composition “The dengue vaccination Qdenga® is a tetravalent live attenuated vaccine. It is produced in Vero cells by recombinant DNA technology and contains serotype-specific surface protein genes of the four dengue serotypes, engineered into a dengue type 2 backbone.” Storage and Presentation “Vaccines should be stored in the original packaging at +2C̊…

Read More

UK vaccination schedule (July 2025)

UK Immunisation Schedule Timeline UK Immunisation Schedule Timeline 8 weeks First vaccinations Diphtheria, tetanus, pertussis Polio, Hib, Hepatitis B Meningococcal group B Rotavirus 12 weeks Second round Diphtheria, tetanus, pertussis Polio, Hib, Hepatitis B MenB Rotavirus 16 weeks Third round Diphtheria, tetanus, pertussis Polio, Hib, Hepatitis B Pneumococcal (13 types) 1 year One year boosters…

Read More

Cefalexin

Nature of the antibiotic Mechanism of action Cefalexin, like other beta-lactams, binds to the penicillin-binding protein (PBP) and prevents peptidoglycan synthesis. It prevents the formation of new cell walls and maintenance of the cell wall leading to autolysis of the bacteria due to osmotic pressure. Mechanism of resistance PK/PD and other properties Indication (cefalexin is…

Read More

Lefamulin

Nature of the antibiotic Semi-synthetic, pleuromutilin class.Molecular weight – 567.79 gm/mole Pleuromutilins Pleuromutilins (produced by Pleurotus sp.), discovered in the 1950s, have a tricyclic mutilin core.Tiamulin – the first member of this group, was approved for veterinary use in 1979.Retapamulin – topical pleuromutilin was approved for human use in 2007. Mechanism of action It inhibits protein…

Read More

Culture media and composition

This is a list of some culture media and their composition. MEDIA SUPPLEMENTS TARGET ORGANISMS ABC plates Alpha-galactosidase Salmonella sp. Alkaline peptone water [pH – 8.6 ± 0.2] NaCl, peptone Enrichment of Vibrio spp. Aztreonam Blood Agar Aztreonam, blood agar base Gram-positive, especially fastidious gram-positive organisms BHI Broths Calf brain and beef heart infusion solids, peptone…

Read More