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Rotavirus vaccine (study note)

Vaccine Efficacy– Protect against gastroenteritis due to rotavirus serotypes G1P, G2P, G3P, G4P, and G9P; some efficacy against uncommon rotavirus genotypes G8P and G12P.– Over 85% effective at protecting against severe rotavirus gastroenteritis in the first two years of life. Administration of the vaccine Rotarix® should not be given to infants under 6 weeks of age.WHO recommends infants should…

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Antifungals – Synergy, indifference and antagonism

A combination of antifungals is often used in cases of difficult-to-treat infections. What is the evidence in the literature about synergy, antagonism and indifference? Drug 1 Drug 2 Candida Aspergillus Cryptococcus neoformans Amphotericin B Echinocandin Indifference(survival – NA) Synergy, Indifference(Survival ↑) Synergy(survival – NA) Amphotericin B Flucytosine Synergy, indifference(Survival ↑) Synergy, indifference, antagonism(Survival ↑) Synergy,…

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M genitalium

Mycoplasma genitalium Antimicrobial Resistance Surveillance (MARS) – Takeaways

MARS 2nd pilot report is out. It included data from all consecutive M. genitalium specimens collected from 15 SHCs between January and March 2020. M. genitalium diagnostic testing was done on1. for those presenting with non-gonococcal urethritis or pelvic inflammatory disease, and2. for the current sex partners of those who tested positive for M. genitalium….

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Turicella otitidis

The Bacteria: Turicella otitidis is an anaerobic, non-motile, pleomorphic, gram-positive bacillus – similar to coryneform but longer.It produces a convex whitish/cream-coloured non-haemolytic colony.CAMP test positiveDNase and Catalase positive.Oxidase negative. It is often misidentified as Corynebacterium by some commercial systems. See the Pinterest images here: Pathogenicity – Otitis media Turicella is a commensal of the external…

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book

What resources do I need to use for FRCPath Microbiology?

FRCPath Microbiology questions are heavily drawn from British and some international guidelines, recent developments relevant to the UK, and recent journal articles (review, meta-analysis, important research articles). Reading books may not be sufficient for these exams, especially for part 2. Here is a list of resources that you should read – Curriculum You must go…

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