Plazomicin
Nature of the antibiotic Class: Next-generation aminoglycoside (neoglycoside), semisynthetic (sisomicin based). It is not inactivated by most aminoglycoside-modifying enzymes (AME).Molecular weight: 592.68. […]
Antibiotic
Tigecycline
Nature: Glycylcycline, a member of the tetracycline family. Semisynthetic derivative of minocycline.MW: 585.6 Mechanism of action: 1. Bind to 30S
Fosfomycin
Nature: Small (Mol weight – 138) phosphoenolpyruvate analogue manufactured synthetically but originally obtained from Streptomyces fradiae and some Pseudomonas sp.A
Ceftolozane-tazobactam
Class: 5th generation cephalosporin.Available as ceftolozane-tazobactam, a beta lactam-beta lactamase inhibitor (BLBLI) combination. Mechanism of Action: Similar to other beta-lactam antibiotics.
Lefamulin
Nature of the antibiotic Semi-synthetic, pleuromutilin class.Molecular weight – 567.79 gm/mole Pleuromutilins Pleuromutilins (produced by Pleurotus sp.), discovered in the
Metronidazole
Class: Nitroimidazole.Mol weight: 171First used in 1960. Mechanism of action: Metronidazole enters the susceptible (bacterial/parasite) cells by passive diffusion. It gets activated to
Mechanism of resistance in Enterococcus
Enterococci are intrinsically resistant to many classes of antibiotics – like cephalosporins, Aminoglycoside (low-level resistance), macrolides, clindamycin, quinupristin-dalfopristin (E faecalis),
Antibiotic – intrinsic resistance
Microorganisms are only listed as “intrinsically resistant” to an agent (or group of agents) when a vast majority of wild-type
Cefalexin
Nature of the antibiotic Mechanism of action Cefalexin, like other beta-lactams, binds to the penicillin-binding protein (PBP) and prevents peptidoglycan