Eikenella corrodens
Bacteria: Pathogenicity: Culture and identification: Infection caused by Eikenella: Points to remember Eikenella corrodens is usually susceptible to: Non-susceptible to:
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Rotavirus vaccine (study note)
Vaccine Efficacy– Protect against gastroenteritis due to rotavirus serotypes G1P, G2P, G3P, G4P, and G9P; some efficacy against uncommon rotavirus genotypes G8P and G12P.– Over 85% effective at protecting against severe rotavirus gastroenteritis in the first two years of life. Administration of the vaccine Rotarix® should not be given to infants under 6 weeks of age.WHO recommends infants should…
Legionella Control in Healthcare
What are the Laws underpinning the Legionella control? There is a hierarchy of laws guiding the Legionella control ACOP L8:2013 The responsibility lies with the owner of the premises or the employer (this person is called the “duty holder”). They must identify and assess the risk, prepare a written scheme to control the risk, implement…
Tigecycline
Nature: Glycylcycline, a member of the tetracycline family. Semisynthetic derivative of minocycline.MW: 585.6 Mechanism of action: 1. Bind to 30S ribosomal subunit and inhibit protein synthesis – It inhibits the attachment of aminoacyl tRNA to the A site and prevents chain elongation, i.e. block the translation process.2. Inhibit mitochondrial protein synthesis by binding to 70…
Echinocandin
Echinocandins are a class of antifungals that prevent glucan synthesis pathways necessary for fungal cell wall formation. Echinocanins are antifungals that are widely used in clinical practice.Three echinocandins are approved for clinical use – Caspofungin, Micafungin and Anidulafungin.A fourth echinocandin – Rezafungin is being developed. Some other antifungals (some in development) that act of fungal cell walls…
Actinotignum schaalii: a new pathogen
An emerging pathogen Actinotignum schaalii gram stain (pic Manurx27, Wikipedia) What infection does it cause, and who is mostly affected? How to identify Actinotignum schaalii in the lab? How do we treat infection caused by Actinotignum schaalii infection? Actinotignum schaalii presentation.(Youtube)