UK SMI notes – Ear Infections

Type of specimen: Ear swab Middle ear fluid Scraping of material from ear canal (for fungal infection) Expected organisms Otitis Externa Acute localised otitis externa Staphylococcus aureus Group A Streptococcus furuncle Erysipelas Acute diffuse otitis externa...

MCQ Mixed set 1

/10 0 votes, 0 avg 17 Mixed Set 1 MCQ - mixed set 1 / 10 A patient presented with a painful genital ulcer with inguinal lymphadenopathy. You have grown a tan, yellow colony - the organism is catalase-negative, oxidase-positive.Which antibiotic is your drug of choice?...

Virus: Cell surface receptors

Virus/family Receptor Herpesvirus HSV: Heparan sulfate, Herpesvirus entry mediator, Nectin EBV: CD21, MHC II CMV: Heparan sulfate, Integrin, PDGF-α receptor HHV6: CD46, CD134 HHV7: CD4 HHV8: Heparan sulfate, Integrin, Ephrin Vaccinia chondroitin sulfate, Heparan...

Virology: Baltimore classification

 Baltimore classification: Classification based on the way the virus generate their mRNA, type of nucleic acid (DNA/RNA, single-stranded/double-stranded, positive or negative sense) Group I: Double-stranded DNA virus (DS-DNA)  Polyomavirus – BK, JC, KI, WU,...

Daptomycin

Class: Cyclic lipopeptide Source: Streptomyces roseosporus Discovered: 1980s; approved for use in 2003 (FDA) Molecular weight: 1620 DA. Immunomodulatory effect: Daptomycin causes limited/no bacterial cell lysis. It also impairs the cell division. This process leads to...

MCQ Mixed set 2

0 Mixed set 2 1 / 10 Pivmecillinam has a high affinity for ______ of E coli. PBP1a PBP2 PBP3 PBP4 PBP5 PBP1a - cefuroxime, cefotaxime, benzylpenicillinPBP2 - mecillinam, clavulinic acid, imipenemPBP3 - cefalexin, piperacillin, moxalactam, mezlocillin, aztreonamPBP4 -...
Adenovirus

Adenovirus

Non-enveloped linear ds-DNA virus. Icosahedral symmetry (70-90 nm diameter). The capsid has three major protein – hexon, penton, and fibre. Adenovirus is being investigated as a vector for vaccine and gene therapy. Ubiquitous in nature. Most people are...
Cefiderocol

Cefiderocol

Class and Chemical structure: Siderophore cephalosporin.  It is a synthetic conjugate, of a cephalosporin moiety and a siderophore moiety. Siderophore moiety bind to the iron and helps the antibiotic to gain entry into bacterial cells using active iron transporters...
Leptospira presentation

Leptospira presentation

Albert Weil described the multisystem disease in 1886. It was called infectious jaundice and often confused with diseases like yellow fever.   First isolated from an autopsy specimen – the patient was suspected of having yellow fever.Many scientists, like...
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