{"id":993,"date":"2025-04-30T18:21:54","date_gmt":"2025-04-30T17:21:54","guid":{"rendered":"https:\/\/microregistrar.com\/?p=993"},"modified":"2025-04-30T18:21:55","modified_gmt":"2025-04-30T17:21:55","slug":"pathogen-associated-histological-features","status":"publish","type":"post","link":"https:\/\/microregistrar.com\/?p=993","title":{"rendered":"Pathogen-Associated Histological Features"},"content":{"rendered":"\n

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Cellular Feature<\/strong><\/td>Associated Pathogen<\/strong><\/td>Description<\/strong><\/td><\/tr><\/thead>
Owl’s eye cells<\/strong><\/td>Cytomegalovirus (CMV)<\/td>Large cells with intracellular inclusions surrounded by a clear halo, resembling an owl’s eye. Pathognomonic of CMV infection<\/a>.<\/td><\/tr>
Decoy cells<\/strong><\/td>BK virus<\/td>Virally infected epithelial cells found in urine. Named for their resemblance to cancer cells, potentially causing diagnostic confusion between viral infection<\/a> and urothelial malignancy.<\/td><\/tr>
Haufen<\/strong><\/td>BK virus<\/td>Icosahedral aggregates of polyomavirus particles and Tamm-Horsfall protein detected in the urine of kidney transplant patients with BKVN using negative-staining electron microscopy.<\/td><\/tr>
Downie bodies<\/strong><\/td>Cowpox virus<\/td>Intracytoplasmic eosinophilic inclusion bodies found in infected epithelial cells.<\/td><\/tr>
Negri bodies<\/strong><\/td>Rabies virus<\/td>Eosinophilic cytoplasmic inclusions found in neurons, particularly in the hippocampus and cerebellum. Considered pathognomonic for rabies infection<\/a>.<\/td><\/tr>
Guarnieri bodies<\/strong><\/td>Vaccinia virus, Variola virus (smallpox)<\/td>Cytoplasmic eosinophilic inclusion bodies in infected epithelial cells.<\/td><\/tr>
Paschen bodies<\/strong><\/td>Variola virus (smallpox)<\/td>Elementary bodies of smallpox virus visible under electron microscopy.<\/td><\/tr>
Bollinger bodies<\/strong><\/td>Fowlpox virus<\/td>Large intracytoplasmic inclusion bodies in infected epithelial cells of birds.<\/td><\/tr>
Molluscum bodies<\/strong><\/td>Molluscum contagiosum virus<\/td>Large intracytoplasmic inclusion bodies (Henderson-Paterson bodies) that push the nucleus to the periphery.<\/td><\/tr>
Cowdry bodies type A<\/strong><\/td>Herpes simplex virus, Varicella-zoster virus<\/td>Eosinophilic intranuclear inclusion bodies surrounded by a clear halo in infected cells.<\/td><\/tr>
Torres bodies<\/strong><\/td>Yellow fever virus<\/td>Acidophilic intranuclear inclusions in hepatocytes.<\/td><\/tr>
Cowdry bodies type B<\/strong><\/td>Poliovirus, Adenovirus<\/td>Basophilic intranuclear inclusions without a clear halo.<\/td><\/tr>
Warthin\u2013Finkeldey bodies<\/strong><\/td>Measles virus, HIV<\/td>Multinucleated giant cells with eosinophilic nuclear inclusions, found in lymphoid tissues.<\/td><\/tr>
Lipschutz bodies<\/strong><\/td>Herpes simplex virus<\/td>Intranuclear eosinophilic inclusions surrounded by a clear halo, similar to Cowdry type A bodies.<\/td><\/tr>
Henderson-Paterson bodies<\/strong><\/td>Molluscum contagiosum virus<\/td>Another name for molluscum bodies; large, intracytoplasmic viral inclusions.<\/td><\/tr>
Babes-Negri bodies<\/strong><\/td>Rabies virus<\/td>Detailed name for Negri bodies; eosinophilic cytoplasmic inclusions in neurons.<\/td><\/tr>
Donovan bodies<\/strong><\/td>Klebsiella granulomatis<\/td>Intracellular rod-shaped bacteria<\/a> seen in granuloma inguinale, appearing as “safety pin” structures when stained.<\/td><\/tr>
Michaelis-Gutmann bodies<\/strong><\/td>Escherichia coli (common)<\/td>Calcified intracellular inclusions seen in malakoplakia, which stain positive with von Kossa and PAS stains.<\/td><\/tr>
Asteroid bodies<\/strong><\/td>Various fungi (Histoplasma, Cryptococcus)<\/td>Star-shaped eosinophilic structures seen in granulomas, particularly in sarcoidosis and fungal infections.<\/td><\/tr>
Coccidioides spherules<\/strong><\/td>Coccidioides immitis\/posadasii<\/td>Large, round structures (30-60 \u00b5m) containing endospores in infected tissues.<\/td><\/tr>
Histoplasma capsulatum<\/strong><\/td>Histoplasma capsulatum<\/td>Small (2-4 \u00b5m) intracellular yeasts in macrophages, visible with silver stains (Grocott’s or Gomori).<\/td><\/tr>
Cryptococcus neoformans<\/strong><\/td>Cryptococcus neoformans<\/td>Mucicarmine-positive yeasts with clear capsular halos in tissues.<\/td><\/tr>
Leishman-Donovan bodies<\/strong><\/td>Leishmania species<\/td>Amastigotes (2-4 \u00b5m) of Leishmania seen within macrophages, containing a nucleus and kinetoplast.<\/td><\/tr>
Sch\u00fcffner’s dots<\/strong><\/td>Plasmodium vivax<\/td>Fine stippling in red blood cells infected with Plasmodium vivax, representing caveolae-vesicle complexes.<\/td><\/tr>
Maurer’s clefts<\/strong><\/td>Plasmodium falciparum<\/td>Coarse dots or clefts in red blood cells infected with Plasmodium falciparum, representing parasite-derived structures.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

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