{"id":457,"date":"2023-07-22T20:38:18","date_gmt":"2023-07-22T19:38:18","guid":{"rendered":"https:\/\/microregistrar.com\/?p=457"},"modified":"2023-07-22T20:38:18","modified_gmt":"2023-07-22T19:38:18","slug":"antifungals-synergy-indifference-and-antagonism","status":"publish","type":"post","link":"https:\/\/microregistrar.com\/?p=457","title":{"rendered":"Antifungals \u2013 Synergy, indifference and antagonism"},"content":{"rendered":"\n

A combination of antifungals is often used in cases of difficult-to-treat infections. What is the evidence in the literature about synergy, antagonism and indifference?<\/p>\n\n\n\n

Drug 1<\/strong><\/td>Drug 2<\/strong><\/td>Candida<\/strong><\/td>Aspergillus<\/strong><\/td>Cryptococcus neoformans<\/strong><\/td><\/td><\/tr>
Amphotericin B<\/td>Echinocandin<\/td>Indifference
(survival \u2013 NA)<\/td>		Synergy, Indifference
(Survival \u2191)<\/td>		Synergy
(survival \u2013 NA)<\/td>		<\/td><\/tr>
Amphotericin B<\/td>Flucytosine<\/td>Synergy, indifference
(Survival \u2191)<\/td>		Synergy, indifference, antagonism
(Survival \u2191)<\/td>		Synergy, indifference, antagonism
(Survival \u2191\/\u2193)<\/td>		<\/td><\/tr>
Amphotericin B<\/td>Azoles<\/td>Antagonism
(Survival \u2194\/\u2193\/\u2191)<\/td>		Synergy, indifference, antagonism
(Survival \u2194\/\u2193)<\/td>		Indifference
(Survival \u2191\/\u2193)<\/td>		<\/td><\/tr>
Echinocandin<\/td>Azoles<\/td>Synergy (Ahmadi 2020<\/a>)<\/td>Synergy, indifference
(Survival \u2191)<\/td>		Indifference
(survival \u2013 NA)<\/td>		<\/td><\/tr>
Azoles<\/td>Flucytosine<\/td>Synergy, indifference, antagonism
(Survival \u2191)<\/td>		<\/td>Synergy, indifference
(Survival \u2191\/\u2193)<\/td>		<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

L.Ostrosky-Zeichner, Combination antifungal therapy: a critical review of the evidence, Clinical Microbiology and Infection Volume 14, Supplement 4, May 2008, Pages 65-70<\/p>\n","protected":false},"excerpt":{"rendered":"

A combination of antifungals is often used in cases of difficult-to-treat infections. What is the evidence in the literature about […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ngg_post_thumbnail":0,"footnotes":""},"categories":[47],"tags":[48,156],"class_list":["post-457","post","type-post","status-publish","format-standard","hentry","category-antifungal","tag-antifungals","tag-synergy"],"_links":{"self":[{"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/posts\/457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=457"}],"version-history":[{"count":1,"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/posts\/457\/revisions"}],"predecessor-version":[{"id":458,"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/posts\/457\/revisions\/458"}],"wp:attachment":[{"href":"https:\/\/microregistrar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=457"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=457"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}