{"id":428,"date":"2023-07-22T14:38:14","date_gmt":"2023-07-22T13:38:14","guid":{"rendered":"https:\/\/microregistrar.com\/?p=428"},"modified":"2023-07-22T14:38:15","modified_gmt":"2023-07-22T13:38:15","slug":"mycoplasma-genitalium-antimicrobial-resistance-surveillance-mars-takeaways","status":"publish","type":"post","link":"https:\/\/microregistrar.com\/?p=428","title":{"rendered":"Mycoplasma genitalium Antimicrobial Resistance Surveillance (MARS) \u2013 Takeaways"},"content":{"rendered":"\n<p>MARS 2nd pilot report is out. It included data from all consecutive M. genitalium specimens collected from 15 SHCs between January and March 2020.<\/p>\n\n\n\n<p>M. genitalium diagnostic testing was done on<br>1. for those presenting with non-gonococcal urethritis or pelvic inflammatory disease, and<br>2. for the current sex partners of those who tested positive for M. genitalium.<\/p>\n\n\n\n<p>Positive results were tested for molecular markers predictive of macrolide and fluoroquinolone resistance in the M. genitalium 23S rRNA and parC genes, respectively.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Points from the report \u2013<\/h2>\n\n\n\n<p><strong>251 sample tested<br>190 (76%) patients were symptomatic<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/microregistrar.com\/wp-content\/uploads\/2021\/09\/image.png\" alt=\"\" class=\"wp-image-7376\"\/><\/figure>\n\n\n\n<p>Of the submitted specimens, 92-93% were tested for resistance. Predicted resistance \u2013<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/microregistrar.com\/wp-content\/uploads\/2021\/09\/image-2.png\" alt=\"\" class=\"wp-image-7378\"\/><\/figure>\n\n\n\n<p>Resistance in specific situations\/group<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/microregistrar.com\/wp-content\/uploads\/2021\/09\/image-3.png\" alt=\"\" class=\"wp-image-7379\"\/><\/figure>\n\n\n\n<p>Macrolide resistance mutations were more commonly detected among specimens from people<br>of Black or Black British (80%) ethnicity and individuals who had a previous sexually transmitted infection (STI) in the past year (79%)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Note:<\/h2>\n\n\n\n<p><strong>Macrolide resistance has previously been reported to be around 40% in the UK,<\/strong> although reference laboratory data shows higher resistance. However, there is a possibility of bias as the sample would have come from those patients who failed treatment. BASHH guideline (2018) commented that \u201cdespite this,<strong> <\/strong><br>M. genitalium still responds to azithromycin in the majority of cases.<strong>\u201d<\/strong><\/p>\n\n\n\n<p>How do the BASHH and CDC guidelines compare<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/microregistrar.com\/wp-content\/uploads\/2021\/09\/bashh-1024x625.png\" alt=\"\" class=\"wp-image-7381\"\/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>MARS 2nd pilot report is out. It included data from all consecutive M. genitalium specimens collected from 15 SHCs between [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":429,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ngg_post_thumbnail":0,"footnotes":""},"categories":[139],"tags":[142,141,140],"class_list":["post-428","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-microbiology-update","tag-mars","tag-mycoplasma-genitalium","tag-update"],"_links":{"self":[{"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/posts\/428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=428"}],"version-history":[{"count":1,"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/posts\/428\/revisions"}],"predecessor-version":[{"id":430,"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/posts\/428\/revisions\/430"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=\/wp\/v2\/media\/429"}],"wp:attachment":[{"href":"https:\/\/microregistrar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/microregistrar.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}