{"id":384,"date":"2023-09-16T22:08:22","date_gmt":"2023-09-16T21:08:22","guid":{"rendered":"https:\/\/microregistrar.com\/?p=384"},"modified":"2023-09-16T22:08:23","modified_gmt":"2023-09-16T21:08:23","slug":"eikenella-corrodens","status":"publish","type":"post","link":"https:\/\/microregistrar.com\/?p=384","title":{"rendered":"Eikenella corrodens"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\"><strong>Bacteria:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Gram-negative fastidious facultative anaerobic bacillus; however, it is pleomorphic and could appear in coccobacillary form.<\/li>\n\n\n\n<li>It is non-motile, non-spore-forming and encapsulated.<\/li>\n\n\n\n<li>It is a member of the oral, gastrointestinal, and genitourinary flora.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Pathogenicity:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Adherence \u2013 lectin-like protein, pilli<\/li>\n\n\n\n<li>Ability to aggregate RBC.<\/li>\n\n\n\n<li>Avoid phagocytosis \u2013 extracellular polysaccharide or slime layer.<\/li>\n\n\n\n<li>Cell wall lipopolysaccharide<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Culture and identification:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Slow-growing, small pin-point colony with a bleach-like smell.<\/li>\n\n\n\n<li>It is yellow-grey with a small greenish discolouration on the blood agar. 50% of colonies are pitting.<\/li>\n\n\n\n<li>It can grow aerobically or anaerobically.<\/li>\n\n\n\n<li>It usually requires hemin (X factor) and carbon dioxide for primary isolation.<\/li>\n\n\n\n<li>Oxidase positive, catalase-negative (some weakly positive), urease negative, indole negative, reduce nitrate.<\/li>\n\n\n\n<li>API20E , (API20NE with additional test)<\/li>\n\n\n\n<li>MALDI ToF<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/microregistrar.com\/wp-content\/uploads\/2021\/07\/image-7.jpeg\" alt=\"\" class=\"wp-image-6482\"\/><figcaption class=\"wp-element-caption\">Eikenella colony (Wikipedia,&nbsp;<a href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:Deminorwood&amp;action=edit&amp;redlink=1\">Deminorwood<\/a>)<\/figcaption><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Infection caused by Eikenella:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Head and neck infection, sinusitis,<\/li>\n\n\n\n<li>Pulmonary infection, septic emboli<\/li>\n\n\n\n<li>Endocarditis<\/li>\n\n\n\n<li>Arthritis, skull infection, vertebral osteomyelitis<\/li>\n\n\n\n<li>Intraabdominal infection, pancreatic abscesses, liver abscess<\/li>\n\n\n\n<li>Chorioamnionitis<\/li>\n\n\n\n<li>Infection after human bite wounds (\u201cclenched-fist injuries\u201d) etc<\/li>\n\n\n\n<li>Skin infection in IVDUs (skin poppers)<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Points to remember<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>It is a member of the HACEK group of organisms and can cause endocarditis (especially in IVDUs or prosthetic valves)<\/li>\n\n\n\n<li>Most infections are polymicrobial.<\/li>\n\n\n\n<li>The patient often has comorbidities like mental retardation with cerebral palsy,&nbsp; head and neck malignancies, Down\u2019s syndrome, diabetes, leukaemia, or trauma history.<\/li>\n\n\n\n<li>Surgical intervention is often required for a successful outcome.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Eikenella corrodens is usually susceptible to:<\/strong><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Penicillin, amoxicillin<\/li>\n\n\n\n<li>First-generation cephalosporins \u2013 variable susceptibility, reported resistance to cephalexin<\/li>\n\n\n\n<li>Second and third-generation cephalosporins<\/li>\n\n\n\n<li>Betalactam-beta-lactamase combination \u2013 coamoxiclav and pip-tazobactam<\/li>\n\n\n\n<li>Tetracyclines<\/li>\n\n\n\n<li>Fluoroquinolones<\/li>\n\n\n\n<li>Cotrimoxazole<\/li>\n<\/ul>\n\n\n\n<p><strong>Non-susceptible to:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Clindamycin<\/li>\n\n\n\n<li>Macrolides \u2013 erythromycin, clarithromycin etc<\/li>\n\n\n\n<li>Aminoglycosides \u2013 gentamicin, amikacin etc<\/li>\n\n\n\n<li>Metronidazole.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Bacteria: Pathogenicity: Culture and identification: Infection caused by Eikenella: Points to remember Eikenella corrodens is usually susceptible to: Non-susceptible to:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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