{"id":380,"date":"2023-09-16T22:09:51","date_gmt":"2023-09-16T21:09:51","guid":{"rendered":"https:\/\/microregistrar.com\/?p=380"},"modified":"2023-09-16T22:09:51","modified_gmt":"2023-09-16T21:09:51","slug":"leclercia-adecarboxylata","status":"publish","type":"post","link":"https:\/\/microregistrar.com\/?p=380","title":{"rendered":"Leclercia adecarboxylata"},"content":{"rendered":"\n

While authorising the urine result \u2013 I found that a urine sample from the community has grown Leclercia adecarboxylata. The patient is a young female complaining of increased frequency. The number of organisms in the urine was >100,000 organisms\/ml.
What is the significance?<\/p>\n\n\n\n

The bacteria<\/strong><\/h4>\n\n\n\n

 Previously known as Escherichia adecarboxylata, it now belongs to a new genus Leclercia (family Enterobacteriaceae).
First described by Leclerc in 1962 as ubiquitous in nature (Food, water etc., animals \u2013 snails).
It is also a member of the gut flora (commensal).<\/p>\n\n\n\n

Identification<\/h4>\n\n\n\n

A motile, aerobic, Gram-negative bacillus<\/p>\n\n\n\n

Positive for<\/strong><\/td>Negative for<\/strong><\/td><\/tr>
Indole production,<\/em> methyl red,<\/em> growth in the presence of KCN,<\/em> malonate utilization,<\/em> esculin hydrolysis,<\/em> gas and acid production
from D-glucose and D-lactose<\/em><\/td>		Voges-Proskauer,<\/em> citrate (Simmons),<\/em> H2S (Kligler),<\/em> amino acid decarboxylases,<\/em> phenylalanine deaminase,<\/em> gelatinase and<\/em> DNase<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Modern identification methods like MALDI-TOF  and 16 s rRNA gene sequencing can distinguish it from phenotypically similar organisms.<\/p>\n\n\n\n

\"Leclercia
Leclercia adecarboxylata colony<\/strong><\/a><\/figcaption><\/figure>\n\n\n\n
\"Leclercia
Leclercia adecarboxylata gram stain<\/strong><\/a><\/figcaption><\/figure>\n\n\n\n

Pathogenesis & pathology<\/h4>\n\n\n\n

Leclercia is an environmental organism but also a member of human bowel flora.
It is considered an opportunistic pathogen, and most cases are reported from immunocompromised patients [Hess, 2008<\/a>].
It is often associated with polymicrobial infection, especially in immunocompetent hosts.
It is a possibility that the organism is often misidentified as E coli as they share many biochemical features.<\/p>\n\n\n\n

The reported cases are \u2013<\/strong><\/p>\n\n\n\n