60-second paper explainer – Lamberink et al. 2026<\/title>\n <style>\n #jm-paper-1397 { --ink:#eef7f5; --muted:#a8c1bd; --teal:#47dbc7; --amber:#ffca6b; --bg:#061615; --panel:#0b2422; width:min(100%,1040px,calc(177.78vh - 132px)); margin:0 auto; color:var(--ink); font-family:Inter,ui-sans-serif,system-ui,-apple-system,\"Segoe UI\",sans-serif; }\n #jm-paper-1397, #jm-paper-1397 * { box-sizing:border-box; }\n #jm-paper-1397 .video { position:relative; overflow:hidden; width:100%; aspect-ratio:16\/9; border-radius:24px; background:\n radial-gradient(circle at 85% 8%,#164a43 0,transparent 30%),\n radial-gradient(circle at 12% 78%,#102e3d 0,transparent 28%),linear-gradient(150deg,#061615,#071d1d 70%,#04100f);\n box-shadow:0 24px 70px #000b; isolation:isolate; }\n #jm-paper-1397 .noise { position:absolute; inset:0; opacity:.035; pointer-events:none; background-image:url(\"data:image\/svg+xml,%3Csvg viewBox='0 0 180 180' xmlns='http:\/\/www.w3.org\/2000\/svg'%3E%3Cfilter id='n'%3E%3CfeTurbulence type='fractalNoise' baseFrequency='.75' numOctaves='3' stitchTiles='stitch'\/%3E%3C\/filter%3E%3Crect width='100%25' height='100%25' filter='url(%23n)'\/%3E%3C\/svg%3E\"); 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min-height:42px; padding:9px 14px; border:0; border-radius:11px; background:#12312e; color:#e8f5f3; font-family:inherit; font-size:14px; font-weight:750; line-height:1.1; cursor:pointer; }\n #jm-paper-1397 button.primary { background:var(--teal); color:#031311; }\n #jm-paper-1397 button:disabled { opacity:.45; cursor:not-allowed; }\n @media (max-width:640px) {\n #jm-paper-1397 .video { border-radius:14px; }\n #jm-paper-1397 .scene { inset:13% 6% 20%; width:88%; }\n #jm-paper-1397 .eye { display:none; }\n #jm-paper-1397 .bars { margin-top:12px; gap:6px; }\n #jm-paper-1397 .bar { height:34px; }\n #jm-paper-1397 .caption { min-height:42px; padding:7px 10px; }\n #jm-paper-1397 .controls { margin-top:6px; }\n #jm-paper-1397 button { min-height:38px; font-size:12px; }\n }\n <\/style>\n<\/head>\n<body>\n <main class=\"shell\" id=\"jm-paper-1397\">\n <section class=\"video\" aria-label=\"Animated journal article explainer\">\n <div class=\"noise\"><\/div>\n <div class=\"brand\"><i><\/i>Journal in a minute<\/div>\n <div class=\"counter\"><span id=\"elapsed\">00<\/span> \/ 55 sec<\/div>\n\n <article class=\"scene active\" data-start=\"0\" data-end=\"6\" data-caption=\"Should every patient with Candida in the bloodstream have an eye examination?\">\n <div class=\"kicker\">Clinical question<\/div>\n <h1>Candida in blood.<br><span class=\"accent\">Look in the eye?<\/span><\/h1>\n <p class=\"sub\">A new multicentre cohort examines the yield – and the uncertainty.<\/p>\n <\/article>\n\n <article class=\"scene\" data-start=\"6\" data-end=\"13\" data-caption=\"Lamberink and colleagues reviewed 402 adults across two Dutch tertiary hospitals over seven years.\">\n <div class=\"kicker\">The cohort<\/div>\n <div class=\"big\">402<\/div>\n <div class=\"label\">adults with candidemia<\/div>\n <div class=\"grid\"><div class=\"card\"><strong>2<\/strong><span>tertiary hospitals<\/span><\/div><div class=\"card\"><strong>7<\/strong><span>years reviewed<\/span><\/div><\/div>\n <\/article>\n\n <article class=\"scene\" data-start=\"13\" data-end=\"22\" data-caption=\"Of 307 examined, 15 had probable ocular candidiasis: 4.9 percent.\">\n <div class=\"eye\"><\/div>\n <div class=\"kicker\">Fundoscopy result<\/div>\n <h2><span class=\"accent\">15 of 307<\/span><br>had probable ocular candidiasis<\/h2>\n <p class=\"sub\">That is 4.9%. Twelve had probable chorioretinitis; three probable endophthalmitis.<\/p>\n <\/article>\n\n <article class=\"scene\" data-start=\"22\" data-end=\"31\" data-caption=\"Crucially, 9 of the 15 - 60 percent - had no visual symptoms or could not report them.\">\n <div class=\"kicker\">The surprise<\/div>\n <div class=\"big\">60%<\/div>\n <h2 style=\"margin-top:24px\">were <span class=\"amber\">silent<\/span> or unable to report symptoms<\/h2>\n <div class=\"flow\"><div class=\"dot\">15<\/div><div class=\"line\"><\/div><div class=\"dot\">9<\/div><\/div>\n <\/article>\n\n <article class=\"scene\" data-start=\"31\" data-end=\"41\" data-caption=\"Every positive examination changed antifungal management, usually by prolonging therapy or adding or switching to an azole.\">\n <div class=\"kicker\">Clinical impact<\/div>\n <h2>Management changed in <span class=\"accent\">all 15<\/span><\/h2>\n <div class=\"bars\">\n <div class=\"bar\"><b style=\"width:100%\"><\/b><span><i>Therapy prolonged<\/i><i>15\/15<\/i><\/span><\/div>\n <div class=\"bar\"><b style=\"width:73%\"><\/b><span><i>Azole added\/switched<\/i><i>11\/15<\/i><\/span><\/div>\n <div class=\"bar\"><b style=\"width:13%\"><\/b><span><i>Intravitreal treatment<\/i><i>2\/15<\/i><\/span><\/div>\n <\/div>\n <\/article>\n\n <article class=\"scene\" data-start=\"41\" data-end=\"48\" data-caption=\"Persistent visual impairment occurred in three patients, and all three were symptomatic from the start.\">\n <div class=\"kicker\">Patient outcome<\/div>\n <div class=\"big amber\">3<\/div>\n <h2 style=\"margin-top:24px\">had persistent visual impairment<\/h2>\n <p class=\"sub\">All three were symptomatic at baseline.<\/p>\n <\/article>\n\n <article class=\"scene\" data-start=\"48\" data-end=\"55\" data-caption=\"The tension: symptom-only screening would miss ocular disease, but this retrospective study does not prove routine screening improves outcomes. Useful evidence - not the final answer.\">\n <div class=\"kicker\">Bottom line<\/div>\n <h2>Symptoms alone <span class=\"amber\">miss disease.<\/span><\/h2>\n <p class=\"warning\">But a retrospective cohort cannot prove that routine fundoscopy improves patient outcomes.<\/p>\n <p class=\"sub\">Useful evidence – not the final answer.<\/p>\n <\/article>\n\n <div class=\"caption\" id=\"caption\">Should every patient with Candida in the bloodstream have an eye examination?<\/div>\n <div class=\"progress\"><i id=\"progress\"><\/i><\/div>\n <\/section>\n <div class=\"controls\">\n <button class=\"primary\" id=\"play\">Play with voiceover<\/button>\n <button id=\"pause\" disabled>Pause<\/button>\n <button id=\"restart\">Restart<\/button>\n <\/div>\n <\/main>\n <script>\n (() => {\n const root = document.querySelector('#jm-paper-1397');\n if (!root || root.dataset.jmReady === '1') return;\n root.dataset.jmReady = '1';\n const DURATION = 55;\n const script = `Should every patient with Candida in the bloodstream have an eye examination? 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{"id":1397,"date":"2026-08-05T21:05:18","date_gmt":"2026-08-05T20:05:18","guid":{"rendered":"https:\/\/microregistrar.com\/?p=1397"},"modified":"2026-08-05T22:50:50","modified_gmt":"2026-08-05T21:50:50","slug":"1-min-micro-ophthalmoscopy-needed-in-invasive-candidiasis","status":"publish","type":"post","link":"https:\/\/microregistrar.com\/?p=1397","title":{"rendered":"1-min-micro: Ophthalmoscopy needed in invasive candidiasis?"},"content":{"rendered":"\n\n\n\n \n \n 60-second paper explainer – Lamberink et al. 2026<\/title>\n <style>\n #jm-paper-1397 { --ink:#eef7f5; --muted:#a8c1bd; --teal:#47dbc7; --amber:#ffca6b; --bg:#061615; --panel:#0b2422; width:min(100%,1040px,calc(177.78vh - 132px)); margin:0 auto; color:var(--ink); font-family:Inter,ui-sans-serif,system-ui,-apple-system,\"Segoe UI\",sans-serif; }\n #jm-paper-1397, #jm-paper-1397 * { box-sizing:border-box; }\n #jm-paper-1397 .video { position:relative; overflow:hidden; width:100%; aspect-ratio:16\/9; border-radius:24px; background:\n radial-gradient(circle at 85% 8%,#164a43 0,transparent 30%),\n radial-gradient(circle at 12% 78%,#102e3d 0,transparent 28%),linear-gradient(150deg,#061615,#071d1d 70%,#04100f);\n box-shadow:0 24px 70px #000b; 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}\n #jm-paper-1397 .progress { position:absolute; z-index:10; left:0; right:0; bottom:0; height:5px; background:#ffffff12; }\n #jm-paper-1397 .progress i { display:block; height:100%; width:0; background:linear-gradient(90deg,var(--teal),var(--amber)); }\n #jm-paper-1397 .controls { display:flex; gap:8px; margin-top:9px; }\n #jm-paper-1397 button { flex:1; min-height:42px; padding:9px 14px; border:0; border-radius:11px; background:#12312e; color:#e8f5f3; font-family:inherit; font-size:14px; font-weight:750; line-height:1.1; cursor:pointer; }\n #jm-paper-1397 button.primary { background:var(--teal); color:#031311; }\n #jm-paper-1397 button:disabled { opacity:.45; cursor:not-allowed; }\n @media (max-width:640px) {\n #jm-paper-1397 .video { border-radius:14px; }\n #jm-paper-1397 .scene { inset:13% 6% 20%; width:88%; }\n #jm-paper-1397 .eye { display:none; }\n #jm-paper-1397 .bars { margin-top:12px; gap:6px; }\n #jm-paper-1397 .bar { height:34px; }\n #jm-paper-1397 .caption { min-height:42px; padding:7px 10px; }\n #jm-paper-1397 .controls { margin-top:6px; }\n #jm-paper-1397 button { min-height:38px; font-size:12px; }\n }\n <\/style>\n<\/head>\n<body>\n <main class=\"shell\" id=\"jm-paper-1397\">\n <section class=\"video\" aria-label=\"Animated journal article explainer\">\n <div class=\"noise\"><\/div>\n <div class=\"brand\"><i><\/i>Journal in a minute<\/div>\n <div class=\"counter\"><span id=\"elapsed\">00<\/span> \/ 55 sec<\/div>\n\n <article class=\"scene active\" data-start=\"0\" data-end=\"6\" data-caption=\"Should every patient with Candida in the bloodstream have an eye examination?\">\n <div class=\"kicker\">Clinical question<\/div>\n <h1>Candida in blood.<br><span class=\"accent\">Look in the eye?<\/span><\/h1>\n <p class=\"sub\">A new multicentre cohort examines the yield – and the uncertainty.<\/p>\n <\/article>\n\n <article class=\"scene\" data-start=\"6\" data-end=\"13\" data-caption=\"Lamberink and colleagues reviewed 402 adults across two Dutch tertiary hospitals over seven years.\">\n <div class=\"kicker\">The cohort<\/div>\n <div class=\"big\">402<\/div>\n <div class=\"label\">adults with candidemia<\/div>\n <div class=\"grid\"><div class=\"card\"><strong>2<\/strong><span>tertiary hospitals<\/span><\/div><div class=\"card\"><strong>7<\/strong><span>years reviewed<\/span><\/div><\/div>\n <\/article>\n\n <article class=\"scene\" data-start=\"13\" data-end=\"22\" data-caption=\"Of 307 examined, 15 had probable ocular candidiasis: 4.9 percent.\">\n <div class=\"eye\"><\/div>\n <div class=\"kicker\">Fundoscopy result<\/div>\n <h2><span class=\"accent\">15 of 307<\/span><br>had probable ocular candidiasis<\/h2>\n <p class=\"sub\">That is 4.9%. Twelve had probable chorioretinitis; three probable endophthalmitis.<\/p>\n <\/article>\n\n <article class=\"scene\" data-start=\"22\" data-end=\"31\" data-caption=\"Crucially, 9 of the 15 - 60 percent - had no visual symptoms or could not report them.\">\n <div class=\"kicker\">The surprise<\/div>\n <div class=\"big\">60%<\/div>\n <h2 style=\"margin-top:24px\">were <span class=\"amber\">silent<\/span> or unable to report symptoms<\/h2>\n <div class=\"flow\"><div class=\"dot\">15<\/div><div class=\"line\"><\/div><div class=\"dot\">9<\/div><\/div>\n <\/article>\n\n <article class=\"scene\" data-start=\"31\" data-end=\"41\" data-caption=\"Every positive examination changed antifungal management, usually by prolonging therapy or adding or switching to an azole.\">\n <div class=\"kicker\">Clinical impact<\/div>\n <h2>Management changed in <span class=\"accent\">all 15<\/span><\/h2>\n <div class=\"bars\">\n <div class=\"bar\"><b style=\"width:100%\"><\/b><span><i>Therapy prolonged<\/i><i>15\/15<\/i><\/span><\/div>\n <div class=\"bar\"><b style=\"width:73%\"><\/b><span><i>Azole added\/switched<\/i><i>11\/15<\/i><\/span><\/div>\n <div class=\"bar\"><b style=\"width:13%\"><\/b><span><i>Intravitreal treatment<\/i><i>2\/15<\/i><\/span><\/div>\n <\/div>\n <\/article>\n\n <article class=\"scene\" data-start=\"41\" data-end=\"48\" data-caption=\"Persistent visual impairment occurred in three patients, and all three were symptomatic from the start.\">\n <div class=\"kicker\">Patient outcome<\/div>\n <div class=\"big amber\">3<\/div>\n <h2 style=\"margin-top:24px\">had persistent visual impairment<\/h2>\n <p class=\"sub\">All three were symptomatic at baseline.<\/p>\n <\/article>\n\n <article class=\"scene\" data-start=\"48\" data-end=\"55\" data-caption=\"The tension: symptom-only screening would miss ocular disease, but this retrospective study does not prove routine screening improves outcomes. Useful evidence - not the final answer.\">\n <div class=\"kicker\">Bottom line<\/div>\n <h2>Symptoms alone <span class=\"amber\">miss disease.<\/span><\/h2>\n <p class=\"warning\">But a retrospective cohort cannot prove that routine fundoscopy improves patient outcomes.<\/p>\n <p class=\"sub\">Useful evidence – not the final answer.<\/p>\n <\/article>\n\n <div class=\"caption\" id=\"caption\">Should every patient with Candida in the bloodstream have an eye examination?<\/div>\n <div class=\"progress\"><i id=\"progress\"><\/i><\/div>\n <\/section>\n <div class=\"controls\">\n <button class=\"primary\" id=\"play\">Play with voiceover<\/button>\n <button id=\"pause\" disabled>Pause<\/button>\n <button id=\"restart\">Restart<\/button>\n <\/div>\n <\/main>\n <script>\n (() => {\n const root = document.querySelector('#jm-paper-1397');\n if (!root || root.dataset.jmReady === '1') return;\n root.dataset.jmReady = '1';\n const DURATION = 55;\n const script = `Should every patient with Candida in the bloodstream have an eye examination? 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