Intrinsic resistance

Enterobacteriaceae

benzylpenicillin, glycopeptides, fusidic acid,

macrolides (with some exceptions1), lincosamides, streptogramins, rifampicin, daptomycin and linezolid

 In addition to that
Klebsiella pneumoniae, Klebsiella oxytoca,
Citrobacter koseri
Amoxicillin, ticarcillin
Enterobacter cloacae complex,
Enterobacter aerogenes
Citrobacter freundii
Amoxicillin, co-amoxiclav, first-generation cephalosporin
Serratia marcescensAmoxicillin, co-amoxiclav, first and second-generation cephalosporins,
tetracycline, doxycycline (not minocycline/ tigecycline), polymyxin/colistin, nitrofurantoin
Proteus mirabilisTetracycline, tigecycline, colistin/ polymyxin, nitrofurantoin
Proteus vulgarisAmoxicillin, first and second-gen cephalosporin (not cefoxitin),
tetracycline, tigecycline, polymyxin/colistin, nitrofurantoin
ProvidenciaAmoxicillin, co-amoxiclav, first and second-gen cephalosporin (not cefoxitin),
tetracycline, tigecycline, polymyxin/colistin, nitrofurantoin
Morganella morganiiAmoxicillin, co-amoxiclav, first-generation cephalosporin
tetracycline, polymyxin/colistin, nitrofurantoin
Yersinia enterocoliticaAmoxicillin, co-amoxiclav, ticarcillin, first-gen cephalosporin and cefoxitin
Yersinia pseudotuberculosisPolymyxin/colistin

 

Non-fermentative Gram-negativeBenzylpenicillin, first and second generation cephalosporins, glycopeptides, fusidic acid, macrolides, lincosamides, streptogramins, rifampicin, daptomycin and linezolid
 In addition to that
AcinetobacterAmoxicillin, coamoxiclav, 1st and 2nd generation cephalosporin, 3rd gen cephalosporin (except ceftazidime),
aztreonam, ertapenem
trimethoprim, fosfomycin, tetracycline and doxycycline (Not minocycline/ tigecycline),
Pseudomonas aeruginosaAmoxicillin, coamoxiclav, 1st and 2nd generation cephalosporin, 3rd gen cephalosporin (except ceftazidime),
ertapenem, chloramphenicol, neomycin & kanamycin (amongst aminoglycoside)
trimethoprim, tetracycline, tigecycline
Stenotrophomonas maltophiliaAmoxicillin, coamoxiclav, ticarcillin (not ticarcillin clavulanic acid), piperacillin, piperacillin-tazobactam,
1st, 2nd and 3rd generation cephalosporin (except ceftazidime),
aztreonam, carbapenems,
aminoglycoside [poor permeability, efflux, AAC(6’)]
B cepaciaAmoxicillin, coamoxiclav, ticarcillin, ticarcillin-clavulanic acid, piperacillin, piperacillin-tazobactam,
1st, 2nd and 3rd generation cephalosporin (except ceftazidime),
aztreonam, ertapenem,
ciprofloxacin, chloramphenicol, aminoglycoside, trimethoprim, fosfomycin, polymyxin/colistin
Elizabethkingia meningosepticaAmoxicillin, coamoxiclav, ticarcillin, ticarcillin-clavulanic acid, piperacillin (not piperacillin-tazobactam),
1st, 2nd, 3rd and 4th generation cephalosporin, carbapenems, aztreonam, polymyxin/colistin
Achromobacter xylosoxydansAmoxicillin, 1st, 2nd and 3rd generation cephalosporin (except ceftazidime), ertapenem

 

Other gram negatives

Haemophilus influenzaeglycopeptides, lincosamides, daptomycin, linezolid.
Fusidic acid, Streptogramin
Moraxella catarrhalisglycopeptides, lincosamides, daptomycin, linezolid.
trimethoprim
Neisseria spp

glycopeptides, lincosamides, daptomycin, linezolid.

Trimethoprim

Campylobacter fetusglycopeptides, lincosamides, daptomycin, linezolid.
Fusidic acid, trimethoprim, Streptogramin, nalidixic acid
Campylobacter jejuni, C coli

glycopeptides, lincosamides, daptomycin, linezolid.

Fusidic acid, trimethoprim, Streptogramin,

Gram positivesintrinsically resistant to aztreonam, temocillin, polymyxin B/colistin and nalidixic acid
 In addition to that
Staph saprophyticusFusidic acid, ceftazidime, Fosfomycin, novobiocin
Staph cohni, S xylosus, S capitisCaftazidime, novobiocin
Staph aureus, other CoNSCeftazidime
StreptococcusFusidic acid, ceftazidime, Aminoglycoside (low level
Enterococcus faecalisFusidic acid, cephalosporins, macrolides, clindamycin, Synercid, sulfonamide
Enterococcus gallinarum, E casseliflavusFusidic acid, cephalosporins, macrolides, clindamycin, Synercid, vancomycin, sulfonamide
Ent faeciumFusidic acid, cephalosporins, macrolides, sulphonamides,
aminoglycosides (Low level + AAC6 – synergism with pen/glycopeptides is only seen with gent/amikacin/Streptomycin)
CorynebacteriumFosfomycin
Listeria monocytogenesCephalosporins
Leuconostoc, Pediococcus, LactobacillusVancomycin, Teicoplanin
Clostridium ramosum, C innocuumVancomycin
?
This website use cookies to improve the site. It helps me to find out which posts are popular. You can opt-out if you wish. Click here to opt out.
×